Patient Profiles
Jesse is a patient living with gMG. Jesse has received compensation from Alexion Pharmaceuticals, Inc.
Patient types that may be appropriate for ULTOMIRIS®

Meet Madison
A 32-year-old recently diagnosed with generalized myasthenia gravis (gMG) and experiencing breakthrough symptomsa
Age: 32 | Profession: Social worker | Length of Disease: 8 months; treatment initiated upon diagnosis | Location: Cleveland, Ohio
Medical history
- Madison has no significant medical history except for a diagnosis of anti-AChR antibody-positive gMG 8 months ago
- Madison has a family history of osteoporosis and diabetes mellitus
History of present illness
- Madison’s disease progressed from oMG to gMG quickly, requiring a steroid and IST for management
- MGFA class IIIa
- MG-ADL total score: 7
-
Madison initially experienced an incomplete response on low-dose steroids
and azathioprine, requiring an escalation to prednisone 60 mg per day
- Madison experienced weight gain and acne requiring a steroid reduction to 20 mg per day
Current medications
- Prednisone 20 mg once daily
- Azathioprine 150 mg once daily
- Pyridostigmine 60 mg four times daily
Current chief complaints
- Madison has an incomplete response to current therapies and is experiencing breakthrough symptoms of intermittent slurring of speech, increased shortness of breath upon exertion, and lower limb paresis
- Madison is continuing to experience gMG symptoms as well as weight gain and increased acne
- Madison is concerned about the increased risk of comorbidities and serious adverse reactions associated with long-term steroid use and ISTs
Do you have a patient like Madison? Learn more about treating earlier with ULTOMIRIS (ravulizumab-cwvz).

Meet Jacob
A 55-year-old father with gMG worried about treatment burdena
Age: 55 | Profession: Grocery clerk | Length of Disease: 2 years | Location: Boston, Massachusetts
Medical History
- Jacob has no significant medical history except for a diagnosis of anti-AChR antibody-positive gMG 2 years ago
History of present illness
- He has been on an infusion therapy with concomitant steroids for the past 6 months
- MGFA class IIa
- His daily medication regimen previously included azathioprine, which was discontinued because he could not tolerate it
- He was still experiencing gMG symptoms, which prompted more frequent doses of infusion therapy
Current medications
- Intravenous immunoglobulin
- Prednisone 20 mg once daily
Current chief complaints
- Despite more frequent infusions, Jacob is still experiencing fluctuating and unpredictable symptoms between treatment doses, making it difficult to drive to work and keep up with his children’s extracurricular activities
- Jacob has concerns about his current treatment regimen due to its unpredictable infusion schedules and frequent lengthy infusion center visits
- Based on conversations with his doctor, Jacob is interested in a treatment option that can help decrease his gMG symptoms, which were evaluated during his MG-ADL assessment
aPatient cases are fictitious and are not intended for diagnosis or treatment
purposes.
Images are not of actual patients.
AChR, acetylcholine receptor; gMG, generalized myasthenia gravis; IST, immunosuppressive
therapy; MG-ADL, Myasthenia Gravis Activities of Daily Living; MGFA, Myasthenia Gravis
Foundation of America; oMG, ocular myasthenia gravis; QMG, Quantitative Myasthenia Gravis.